Thrombotic disorders arise when clots form in blood vessels. Clots in such places as the coronary artery, lungs, and brain can lead to death. Because clots form differently in arteries and veins, drug development processes are generally broken down into two categories: those that focus on antiplatelet agents and those that focus on anticoagulants. In the United States and Europe, Daiichi Sankyo has already launched the antiplatelet agent Effient® / Efient® (Prasugrel), which targets platelet aggregation in arteries. The company is also conducting clinical trials of the anticoagulant DU-176b (Edoxaban), which targets a blood coagulation factor in veins. Covering a wide range of thrombotic disorders with these two agents, we believe that Daiichi Sankyo is capable of becoming the leader in antithrombotic agents.
Daiichi Sankyo has extensive experience with blood coagulation. In 1952, Shosuke Okamoto, a scientist at Kobe University, discovered the first antiplasmin agent called epsilon-aminocaproic acid. It was further developed by Daiichi, has been marketed as Ipsilon® since 1962 and was the world's first anti-plasmin medicine. Plasmins are enzymes that play a key role in blood thinning. Therefore, the anti-plasmin is used to promote blood coagulation when patients are experiencing serious bleeding, among other things. The development of Ipsilon® was only one of the first steps in the company's extensive research activities in the field of haemostasis. Daiichi later found various factor Xa inhibitor candidates that prevent blood clotting. These extensive research experience has led to the development of edoxaban, an oral factor Xa inhibitor that is currently available in Japan for the prevention venous thromboembolism in patients under going orthopaedic surgery.